Anti-Fibronectin, clone TV-1

Anti-Fibronectin, clone TV-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2125SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Fibronectin is a soluble dimeric... more
Product information "Anti-Fibronectin, clone TV-1"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Fibronectin is a soluble dimeric glycoprotein of 440kDa, which is present in cells, extracellular matrix, and blood. There are two types of fibronectin: soluble fibronectin which is produced by hepatocytes and found in blood plasma, and insoluble cellular fibronectin which is produced by fibroblasts in a soluble form and latter assembled into an insoluble form via fibril formation.This antibody reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this antibody localizes to tumor vessels where it binds to the underlying basement. The Fibronectin epitope recognized by this antibody is not accessible in normal tissues to the circulating antibody indicating that it can be used to specifically target tumor vessels in vivo. Clone TV-1 fibronectin antibody is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or antibodies. Protein function: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. [The UniProt Consortium]
Keywords: Anti-FN, Anti-FN1, Fibronectin Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V2125SAF

Properties

Application: FC, IHC, IF
Antibody Type: Monoclonal
Clone: TV-1
Conjugate: No
Host: Mouse
Species reactivity: human, swine, mouse, rat
Immunogen: A T-cell lymphoma biopsy was used as the immunogen for this fibronectin antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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