Anti-FIBP

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], Protein function: May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Nucleus. Endomembrane system, Peripheral membrane protein. Also associated with cytoplasmic membranes, particularly of mitochondria.