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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F44217-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F44217-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. FGFR3 is a receptor for acidic and basic fibroblast... more
Product information "Anti-FGFR3"
In 1X PBS, pH 7.4, with 0.09% sodium azide. FGFR3 is a receptor for acidic and basic fibroblast growth factors. Preferentially binds FGF1. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, STAT5A and STAT5B. Plays a role in postnatal lung development. [The UniProt Consortium]
Keywords: | Anti-Mfr3, Anti-CD333, Anti-Fgfr3, Anti-FGFR-3, EC=2.7.10.1, Anti-Fibroblast growth factor receptor 3, Anti-Heparin-binding growth factor receptor, FGFR3 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F44217 |
Properties
Application: | IHC, WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | A portion of amino acids 468-495 from the mouse protein was used as the immunogen for this FGFR3 antibody. |
Format: | Purified |
Database Information
UniProt ID : | Q61851 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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