Anti-FGFR1 N-terminal

Anti-FGFR1 N-terminal
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NB-26386 100 µl - -

3 - 16 business days*

717.00€
 
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50%... more
Product information "Anti-FGFR1 N-terminal"
Concentration: 1 mg/ml. Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. [The UniProt Consortium]
Keywords: Anti-BFGFR, Anti-FLT-2, Anti-FGFR1, Anti-N-sam, Anti-CD331, Anti-FGFR-1, Anti-bFGF-R-1, Anti-Proto-oncogene c-Fgr, Anti-Fms-like tyrosine kinase 2, Anti-Fibroblast growth factor receptor 1, Anti-Basic fibroblast growth factor receptor 1
Supplier: NewEast Biosciences
Supplier-Nr: 26386

Properties

Application: ELISA, WB, IHC
Antibody Type: Monoclonal
Conjugate: No
Host: Mouse
Species reactivity: vertebrates
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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