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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V7770-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V7770-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This gene encodes a receptor that... more
Product information "Anti-FCGRT, clone FCGRT/2932"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation. Protein function: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). [The UniProt Consortium]
Keywords: | Anti-FcRn, Anti-FCRN, Anti-FCGRT, Anti-Neonatal Fc receptor, Anti-IgG receptor FcRn large subunit p51, Anti-IgG Fc fragment receptor transporter alpha chain, FCGRT Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V7770 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | FCGRT/2932 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A recombinant human partial protein (amino acids 24-215) |
Format: | Purified |
Database Information
KEGG ID : | K24019 | Matching products |
UniProt ID : | P55899 | Matching products |
Gene ID | GeneID 2217 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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