Anti-FBXW4, CT (F-box/WD Repeat-containing Protein 4, F-box and WD-40 Domain-containing Protein 4, D

Anti-FBXW4, CT (F-box/WD Repeat-containing Protein 4, F-box and WD-40 Domain-containing Protein 4, D
Item number Size Datasheet Manual SDS Delivery time Quantity Price
F0024-74.200 200 µl - -

3 - 19 business days*

728.00€
 
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins... more
Product information "Anti-FBXW4, CT (F-box/WD Repeat-containing Protein 4, F-box and WD-40 Domain-containing Protein 4, D"
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds, disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-F-box/WD repeat-containing protein 4, Anti-F-box and WD-40 domain-containing protein 4
Supplier: United States Biological
Supplier-Nr: F0024-74

Properties

Application: ELISA, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic peptide selected from the C-terminal region of human FBXW4 (KLH).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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