Anti-FBXO11

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA002690.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA002690.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3... more

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Product information "Anti-FBXO11"

Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 100%

Keywords:	Anti-FBX11, Anti-VIT-1, Anti-FBXO11, Anti-UG063H01, Anti-F-box only protein 11, Anti-Vitiligo-associated protein 1, Anti-Protein arginine N-methyltransferase 9
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA002690

Properties

Application:	ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: GHRAKRARVS GKSQDLSAAP AEQYLQEKLP DEVVLKIFSY LLEQDLCRAA CVCKRFSELA NDPILWKRLY MEVFEYTRPM MHPEPGKFYQ INPEEYEHPN PWKESFQQLY KGAHVKPGFA EHFYSNPARY KGR (ATA-APrEST77465)