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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A301-178A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A301-178A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3... more
Product information "Anti-FBXO11"
Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. [The UniProt Consortium]
Keywords: | Anti-VIT-1, Anti-FBX11, Anti-FBXO11, Anti-UG063H01, Anti-F-box only protein 11, Anti-Vitiligo-associated protein 1, Anti-Protein arginine N-methyltransferase 9 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A301-178A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse, rat) |
Immunogen: | synthetic peptide. The epitope recognized by A301-178A-T maps to a region between residue 877 and 927 of human F-box only protein 11 using the numbering given in entry AAV87312.1 (GeneID 80204). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K10297 | Matching products |
UniProt ID : | Q86XK2 | Matching products |
Gene ID | GeneID 80204 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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