Anti-FBXO11

Anti-FBXO11
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-178A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A301-178A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3... more
Product information "Anti-FBXO11"
Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. [The UniProt Consortium]
Keywords: Anti-VIT-1, Anti-FBX11, Anti-FBXO11, Anti-UG063H01, Anti-F-box only protein 11, Anti-Vitiligo-associated protein 1, Anti-Protein arginine N-methyltransferase 9
Supplier: Bethyl Laboratories
Supplier-Nr: A301-178A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, rat)
Immunogen: synthetic peptide. The epitope recognized by A301-178A-T maps to a region between residue 877 and 927 of human F-box only protein 11 using the numbering given in entry AAV87312.1 (GeneID 80204).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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