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FARP2 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2) is a Protein Coding gene. Diseases associated with FARP2 include Pseudohypoparathyroidism Ia and Aarskog-Scott Syndrome. Among its related pathways are Development Endothelin-1/EDNRA signaling and Focal Adhesion. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is FARP1. Protein function: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. [The UniProt Consortium]
Keywords:
Anti-FIR, Anti-FARP2, Anti-KIAA0793, Anti-FERM domain-including RhoGEF, Anti-PH domain-containing family C member 3, Anti-FERM, ARHGEF and pleckstrin domain-containing protein 2, Anti-Pleckstrin homology domain-containing family C member 3, Anti-FERM, FAR
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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