Anti-EYA3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-690A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A302-690A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone... more

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Product information "Anti-EYA3"

Protein function: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye. [The UniProt Consortium]

Keywords:	Anti-EYA3, Anti-Eyes absent homolog 3
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-690A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan, rhesus monkey, gorilla, white-tufted-ear marmoset, crab-eating macaque, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A302-690A-T maps to a region between residue 30 and 60 of human eyes absent homolog 3 using the numbering given in entry NP_001981.2 (GeneID 2140).
Format:	Antigen Affinity Purified