Anti-EXOSC10

Anti-EXOSC10
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-989A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-989A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-989A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Putative catalytic component of the RNA exosome complex which has 3'->5'... more
Product information "Anti-EXOSC10"
Protein function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. [The UniProt Consortium]
Keywords: Anti-PMSCL, Anti-EXOSC10, Anti-PM/Scl-100, EC=3.1.13.-, Anti-Autoantigen PM/Scl 2, Anti-Exosome component 10, Anti-Polymyositis/scleroderma autoantigen 2, Anti-Polymyositis/scleroderma autoantigen 100 kDa
Supplier: Bethyl Laboratories
Supplier-Nr: A303-989A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset)
Immunogen: synthetic peptide. The epitope recognized by A303-989A-T maps to a region between residue 835 to 885 of human Exosome Component 10 using the numbering given in entry NP_001001998.1 (GeneID 5394).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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