Anti-Estrogen Inducible Protein pS2 / TFF1, clone TFF1/2969R

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7460IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-Estrogen Inducible Protein pS2 / TFF1, clone TFF1/2969R"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. It is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy. Protein function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. [The UniProt Consortium]
Keywords: Anti-TFF1, Anti-BCEI, Anti-hP1.A, Anti-PNR-2, Anti-Protein pS2, Anti-Trefoil factor 1, Anti-Polypeptide P1.A, Anti-Breast cancer estrogen-inducible protein, Estrogen Inducible Protein pS2 / TFF1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V7460IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: TFF1/2969R
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Amino acids CFDDTVRGVPWCFYPNTIDVPPEEECEF
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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