Anti-Estrogen Inducible Protein pS2 (TFF1), clone SPM313

Anti-Estrogen Inducible Protein pS2 (TFF1), clone SPM313
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2879SAF-100UG 100 µg - -

3 - 10 business days

1 mg/ml in sterile PBS, BSA free, sodium azide free. It recognizes a polypeptide of 6.5kDa,... more
Product information "Anti-Estrogen Inducible Protein pS2 (TFF1), clone SPM313"
1 mg/ml in sterile PBS, BSA free, sodium azide free. It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy. Protein function: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. [The UniProt Consortium]
Keywords: Anti-BCEI, Anti-TFF1, Anti-hP1.A, Anti-PNR-2, Anti-Protein pS2, Anti-Trefoil factor 1, Anti-Polypeptide P1.A, Anti-Breast cancer estrogen-inducible protein, Estrogen Inducible Protein pS2 Antibody (TFF1)
Supplier: NSJ Bioreagents
Supplier-Nr: V2879SAF-100UG


Application: FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM313
Conjugate: No
Host: Mouse
Reactivity: Human, Cynomolgus Monkey
Immunogen: Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from human pS2.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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