Anti-ERK5

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-656A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A302-656A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Plays a role in various cellular processes such as proliferation,... more

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Product information "Anti-ERK5"

Protein function: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. [The UniProt Consortium]

Keywords:	Anti-BMK1, Anti-MAPK7, Anti-ERK-5, Anti-BMK-1, Anti-MAPK 7, EC=2.7.11.24, Anti-MAP kinase 7, Anti-Big MAP kinase 1, Anti-Mitogen-activated protein kinase 7, Anti-Extracellular signal-regulated kinase 5
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-656A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A302-656A-T maps to a region between residue 766 and 816 of human extracellular-signal-regulated kinase 5 using the numbering given in entry NP_002740.2 (GeneID 5598).
Format:	Antigen Affinity Purified