Anti-ERK2 Internal DyLight(TM)800, clone 3H9.A1.A8, DyLight(TM) 800 Conjugated

Anti-ERK2 Internal DyLight(TM)800, clone 3H9.A1.A8, DyLight(TM) 800 Conjugated
Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-345-GQ1S 25 µl - -

6 - 10 business days*

180.00€
 
This DyLight(TM)800 conjugated protein A purified mouse monoclonal antibody reacts specifically... more
Product information "Anti-ERK2 Internal DyLight(TM)800, clone 3H9.A1.A8, DyLight(TM) 800 Conjugated"
This DyLight(TM)800 conjugated protein A purified mouse monoclonal antibody reacts specifically with human ERK2. Anti-ERK2 is purified from tissue culture supernatant by protein A purification. Cross reactivity is expected to occur with human, mouse, and rat based on sequence identity of the peptide immunogen. This antibody does not react with the ERK1 isoform. Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2. [The UniProt Consortium]
Keywords: Anti-ERK2, Anti-ERT1, Anti-ERK-2, Anti-MAPK1, Anti-MAPK 1, Anti-MAPK 2, Anti-p42-MAPK, Anti-MAP kinase 1, Anti-MAP kinase 2, EC=2.7.11.24, Anti-MAP kinase isoform p42, Anti-Mitogen-activated protein kinase 2, Anti-Mitogen-activated protein kinase 1
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-345-GQ1S

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 3H9.A1.A8
Conjugate: No
Host: Mouse
Species reactivity: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acid residues near an internal region of ERK2 conjugated to KLH.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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