Anti-Epstein Barr Virus, clone CS1-4 (Monoclonal) [Mouse]

MON3274 targets the 60 kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the Epstein-Barr virus. There is cross-reactivity with Reed Sternberg cells of Hodgkin's disease. The EpsteinBarr virus is an important as a cause of Infectious mononucleosis and has been associated with oral carcinomas. Protein function: Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF- kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. [The UniProt Consortium]