Anti-Eph Receptor A5 / EphA5

Anti-Eph Receptor A5 / EphA5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R32140 100 µg - -

3 - 10 business days

503.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. EPH receptor A5 (ephrin type-A receptor 5)... more
Product information "Anti-Eph Receptor A5 / EphA5"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. Protein function: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion. [The UniProt Consortium]
Keywords: Anti-BSK, Anti-EK7, Anti-hEK7, Anti-EPHA5, Anti-EHK-1, EC=2.7.10.1, Anti-EPH-like kinase 7, Anti-EPH homology kinase 1, Anti-Brain-specific kinase, Anti-Ephrin type-A receptor 5, Eph Receptor A5 Antibody / EphA5
Supplier-Nr: R32140

Properties

Application: WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Amino acids TLEDLRRLGVTLVGHQKKIMNSLQEMKVQ LVN of human Eph receptor A5 were used as the immunogen for the Eph Receptor A5 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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