Anti-EPCR/CD201 Rabbit Monoclonal Antibody (Clone 041)

Endothelial protein C receptor (EPCR), also known as CD201, is a type I transmembrane glycoprotein involved in coagulation and hemostasis, cytoprotection, and innate immunity. It is composed of a signal peptide, alpha1 and alpha2 domains, which share homology with CD1d and bind to phosphatidylcholine, a transmembrane domain, and a cytoplasmic tail. EPCR is expressed on the surface of endothelial cells and can be cleaved by disintegrin and metalloproteinase domain-containing protein 17 (ADAM17/TACE) to release soluble EPCR, which is a process known as shedding and is induced by thrombin and pro-inflammatory mediators, including IL-1beta, TNF-alpha, and phorbol esters. Binding of protein C to EPCR facilitates its activation by the thrombin-thrombomodulin complex, which can then inactivate factor Va and factor VIIIa to promote anticoagulation, and EPCR-associated activated protein C cleaves proteinase-activated receptor 1 (PAR1) to initiate cytoprotective signaling. EPCR is also involved in inflammation, malaria pathogenesis, and cancer metastasis. Knockout of EPCR protects against needle-induced joint bleeding in a mouse model of hemophilia A. SNPs in EPCR are associated with venous thromboembolism (VTE). Cayman's EPCR/CD201 Rabbit Monoclonal Antibody (Clone 041) can be used for immunohistochemistry paraffin (IHC-P).Synonyms: Activated Protein C Receptor, APC Receptor, Endothelial Cell Protein C Receptor, Endothelial Protein C Receptor, PROCR, Protein C Receptor. Immunogen: Recombinant human EPCR. Clone Designation: 041. Formulation: (Request formulation change), 50 or 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Rabbit. Isotype: IgG. Applications: IHC-P. Cross Reactivity: (+) EPCR.