Anti-EPCAM

Anti-EPCAM
Item number Size Datasheet Manual SDS Delivery time Quantity Price
030168.100 100 µl - -

3 - 19 business days*

477.00€
 
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at... more
Product information "Anti-EPCAM"
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.Tissue specificity: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas.ABCAM:Epithelial Cell Adhesion Molecule (EpCAM) is a 40kD cell surface antigen. This antigen has been identified independently by a number of groups, and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM, many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium.BIOLEGEND:This cell surface, glycosyl,ated 40kD protein is highly expressed in the bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin. Applications: Western Bloting: 1:500-1:2000., Immunohistochemistry: 1:200-1:1000., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-EGP, Anti-KSA, Anti-EPCAM, Anti-CD326, Anti-Ep-CAM, Anti-EGP314, Anti-hEGP314, Anti-GA733-2, Anti-KS 1/4 antigen, Anti-Epithelial glycoprotein, Anti-Epithelial glycoprotein 314, Anti-Epithelial cell surface antigen
Supplier: United States Biological
Supplier-Nr: 030168

Properties

Application: ELISA, IHC, WB
Antibody Type: Monoclonal
Clone: 13B246
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Purified recombinant fragment of human EPCAM expressed in E. coli.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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