Anti-EPC1

Polyclonal Antibody against Human EPC1, Gene description: enhancer of polycomb homolog 1, Alternative Gene Names: Epl1, Validated applications: ICC, Uniprot ID: Q9H2F5, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. [The UniProt Consortium] Mouse gene identity: 89% Rat gene identity: 89%