Anti-ELF3 / E74-like factor 3

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The ELF3 antibody targets E74-like factor 3, a transcription factor encoded by the ELF3 gene that belongs to the ETS (E26 transformation-specific) family of DNA-binding proteins. E74-like factor 3 acts as an epithelial cell-specific transcriptional activator regulating genes involved in differentiation, barrier formation, and immune response. It binds ETS consensus sequences in gene promoters to modulate expression of epithelial keratins, claudins, and cytokines. The ELF3 antibody provides researchers with a powerful tool for exploring epithelial gene regulation, development, and cancer biology.E74-like factor 3 contains a highly conserved ETS DNA-binding domain and transcriptional activation region that interact with coactivators such as CBP/p300. It is predominantly expressed in epithelial tissues including the gastrointestinal tract, lung, and mammary gland. The ELF3 antibody enables visualization of nuclear expression patterns in these tissues and supports mechanistic studies of epithelial-specific gene networks. In normal physiology, ELF3 regulates differentiation of epithelial cells by coordinating transcription of structural and signaling molecules necessary for tissue integrity.Aberrant expression of ELF3 has been linked to carcinogenesis, especially in colorectal, breast, and bladder cancers. It may function as either a tumor suppressor or oncogene depending on context, influencing cell proliferation, invasion, and response to inflammatory cytokines. The ELF3 antibody allows quantitative and localization-based studies of this transcription factor in tumor samples, contributing to identification of prognostic markers and molecular subtypes. It also facilitates exploration of ELF3's interaction with beta-catenin and NF-?B pathways, which connect epithelial transcription programs to inflammation and cancer progression.In immune regulation, E74-like factor 3 drives transcription of chemokines and adhesion molecules that coordinate epithelial immune responses to pathogens and injury. The ELF3 antibody supports studies into these processes, revealing how epithelial tissues integrate immune and barrier functions. Furthermore, ELF3 participates in developmental processes such as endoderm differentiation and organ morphogenesis by directing epithelial lineage specification. Its dysregulation in early development may contribute to congenital anomalies and tissue remodeling defects.NSJ Bioreagents provides the ELF3 antibody as a validated reagent for western blotting, immunofluorescence, and immunohistochemistry. It produces strong nuclear staining consistent with ELF3's transcriptional role. By enabling accurate detection of E74-like factor 3, this antibody supports comprehensive research into epithelial differentiation, inflammation, and tumorigenesis. The ELF3 antibody remains an essential reagent for understanding transcriptional control in epithelial biology and disease.