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Protein function: Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. [The UniProt Consortium]
synthetic peptide. The epitope recognized by A301-744A-T maps to a region between residue 75 and 125 of human eukaryotic translation initiation factor 5B using the numbering given in entry NP_056988.3 (GeneID 9669).
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