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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA001619.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-HPA001619.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: EIF4E-binding protein that regulates translation and stability of mRNAs in... more
Product information "Anti-EIF4ENIF1"
Protein function: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis. Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P- bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 93% and to rat: 95%
Keywords: | Anti-4E-T, Anti-eIF4E transporter, Anti-Eukaryotic translation initiation factor 4E transporter, Anti-Eukaryotic translation initiation factor 4E nuclear import factor 1 |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA001619 |
Properties
Application: | ICC, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: FAPIPLEDHA ENKVDILEML QKAKVDLKPL LSSLSANKEK LKESSHSGVV LSVEEVEAGL KGLKVDQQVK NSTPFMAEHL EETLSAVTNN RQLKKDGDMT AFNKLVSTMK ASGTLPSQPK VSRNLESHLM SPAEI (ATA-APrEST73539) |
Database Information
KEGG ID : | K18728 | Matching products |
UniProt ID : | Q9NRA8 | Matching products |
Gene ID | GeneID 56478 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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