Anti-eIF3A/eIF3S10

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-003A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-003A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-003A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3)... more
Product information "Anti-eIF3A/eIF3S10"
Protein function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). [The UniProt Consortium]
Keywords: Anti-eIF3a, Anti-eIF3 p185, Anti-eIF3 p167, Anti-eIF3 p180, Anti-eIF-3-theta, Anti-Eukaryotic translation initiation factor 3 subunit A, Anti-Eukaryotic translation initiation factor 3 subunit 10
Supplier: Bethyl Laboratories
Supplier-Nr: A302-003A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat)
Immunogen: synthetic peptide. The epitope recognized by A302-003A-T maps to a region between residue 860 and 910 of human translation initiation factor 3 subunit A (eukaryotic translation initiation factor 3, subunit 10) using the numbering given in entry NP_003741.1 (GeneID 8661).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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