Anti-EIF2B (EIF2S2)

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Eukaryotic translation initiation factor 2 subunit 2, also called EIF2B, is a protein that in humans is encoded by the EIF2S2 gene. This gene belongs to the EIF-2-beta family. Eukaryotic translation initiation factor 2 (EIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF2 complex for another round of initiation. Protein function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. [The UniProt Consortium]