Anti-EGR1

Anti-EGR1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ4357 100 µg - -

3 - 10 business days*

549.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Early growth response protein 1, also... more
Product information "Anti-EGR1"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Early growth response protein 1, also known as ZIF268 or NGFIA, is a protein that in humans is encoded by the EGR1 gene. The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. This gene is mapped to 5q31.2. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity. Protein function: Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double- stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia, regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary. [The UniProt Consortium]
Keywords: Anti-EGR1, Anti-AT225, Anti-EGR-1, Anti-KROX24, Anti-NGFI-A, Anti-Zinc finger protein 225, Anti-Transcription factor Zif268, Anti-Transcription factor ETR103, Anti-Zinc finger protein Krox-24, Anti-Early growth response protein 1, EGR1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: RQ4357

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: A recombinant human protein corresponding to amino acids A239-R327 was used as the immunogen for the EGR1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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