Anti-EGFL7 / EGF-like domain-containing protein 7, clone EGFL7/9499

1 mg/ml in 1X PBS, BSA free, sodium azide free. Epidermal Growth Factor-Like Protein 7 antibody, also known as EGFL7 antibody, recognizes a secreted extracellular matrix-associated protein commonly referred to as EGF-like domain-containing protein 7 and Vascular endothelial statin. Epidermal Growth Factor-Like Protein 7 is encoded by the EGFL7 gene located on chromosome 9q34 and is predominantly expressed by endothelial cells. The protein is secreted into the extracellular space, where it incorporates into the vascular basement membrane and contributes to vascular integrity and remodeling. EGFL7 expression is particularly elevated during embryonic angiogenesis and in tissues undergoing active vascular remodeling.Epidermal Growth Factor-Like Protein 7 functions as a regulator of endothelial cell adhesion, migration, and tubule formation. It plays a key role in vascular lumen formation and stabilization of endothelial architecture. EGFL7 antibody is widely used in studies of angiogenesis, tumor-associated neovascularization, and vascular development. The protein has also been shown to modulate Notch signaling in endothelial cells, influencing vascular patterning and differentiation during development.Structurally, Epidermal Growth Factor-Like Protein 7 contains multiple epidermal growth factor-like repeats that mediate interactions with integrins and other extracellular matrix components. Through these domains, EGFL7 supports endothelial cell-matrix communication and maintains vascular stability. Its expression is developmentally regulated, with high levels in embryonic vasculature and more restricted expression in adult tissues except during repair, inflammation, or tumor angiogenesis.Dysregulated EGFL7 expression has been associated with cancer progression and metastasis. Increased EGFL7 levels are observed in colorectal, breast, and hepatocellular carcinomas, where enhanced angiogenesis supports tumor growth and dissemination. Because EGFL7 is largely endothelial-specific, it serves as a valuable marker for studying tumor vasculature and vascular remodeling processes. Its extracellular localization also makes it of interest in therapeutic strategies targeting angiogenesis.Epidermal Growth Factor-Like Protein 7 antibody supports research in vascular biology, angiogenesis, and tumor microenvironment signaling. Clone EGFL7/9499 recognizes EGFL7 and is suitable for detecting Epidermal Growth Factor-Like Protein 7 expression in relevant research applications.