Anti-EGFL7 / EGF-like domain-containing protein 7, clone EGFL7/9497

0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide. EGFL7 antibody, also known as EGF-like domain-containing protein 7 antibody, recognizes a secreted extracellular matrix-associated protein commonly referred to as Epidermal growth factor-like protein 7 and Vascular endothelial statin. EGF-like domain-containing protein 7 is encoded by the EGFL7 gene located on chromosome 9q34 and is predominantly expressed by endothelial cells. The protein is secreted into the extracellular space, where it associates with the vascular basement membrane and plays an important role in angiogenesis and vascular development. EGFL7 expression is particularly prominent during embryogenesis and in actively remodeling vasculature.EGF-like domain-containing protein 7 functions as a regulator of endothelial cell adhesion, migration, and tubulogenesis. It contributes to vascular lumen formation and maintains endothelial integrity by modulating interactions between endothelial cells and the extracellular matrix. EGFL7 antibody is commonly used in studies investigating angiogenesis, vascular morphogenesis, and tumor-associated neovascularization. The protein is also implicated in Notch signaling modulation, influencing endothelial differentiation and vascular patterning.Structurally, EGF-like domain-containing protein 7 contains multiple epidermal growth factor-like repeats that mediate protein-protein interactions within the extracellular matrix. Through these domains, EGFL7 interacts with integrins and other matrix components to regulate endothelial cell behavior. Its expression is tightly controlled during development, with high levels observed in embryonic vasculature and reduced expression in most normal adult tissues, except in sites of active vascular remodeling or repair.Dysregulated EGFL7 expression has been associated with tumor progression and metastasis. Elevated levels are observed in various cancers, including colorectal, breast, and hepatocellular carcinoma, where increased vascularization supports tumor growth. Because EGFL7 is largely endothelial-specific, it serves as a useful marker for studying tumor vasculature and angiogenic processes. Its extracellular localization also makes it of interest in therapeutic targeting strategies aimed at modulating angiogenesis.EGFL7 antibody supports research into vascular biology, developmental angiogenesis, and tumor microenvironment signaling. Clone EGFL7/9497 recognizes EGF-like domain-containing protein 7 and is suitable for detecting EGFL7 expression in relevant research applications.