Anti-EDD1

Anti-EDD1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-045A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-045A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-045A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway.... more
Product information "Anti-EDD1"
Protein function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. [The UniProt Consortium]
Keywords: Anti-EDD, Anti-UBR5, Anti-hHYD, EC=2.3.2.26, Anti-Progestin-induced protein, Anti-E3 ubiquitin-protein ligase UBR5, Anti-Hyperplastic discs protein homolog, Anti-HECT-type E3 ubiquitin transferase UBR5, Anti-E3 ubiquitin-protein ligase
Supplier: Bethyl Laboratories
Supplier-Nr: A303-045A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat)
Immunogen: synthetic peptide. The epitope recognized by A303-045A-T maps to a region between residue 2749 and 2799 of human E3 Ubiquitin Protein Ligase, HECT domain using the numbering given in entry NP_056986.2 (GeneID 51366).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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