Anti-ECI1 (3, 2-trans-enoyl-CoA isomerase, Delta(3), Delta(2)-enoyl-CoA isomerase)

ECI1/DCI(Dodecenoyl-CoA Delta Isomerase), also known as 3,2-trans-enoyl-CoA isomerase, is an , enzyme that catalyzes the conversion of cis-or trans-double bonds of fatty acids at gamma-carbon, (position 3) to trans double bonds at beta-carbon (position 2). It plays a particularly important role in the , metabolism of unsaturated fatty acids. All classes of enoyl-CoA isomerases belong to a family of , enzymes, the hydratase/isomerase or crotonase superfamily, and when examined with x-ray , crystallography, exhibit a common structural feature of the family, the N-terminal core with a spiral fold , composed of four turns, each turn consisting of two beta-sheets and one alpha-helix. Dodecenoyl-CoA , Delta Isomerase is involved in the beta-oxidation, one of the most frequently used pathways in fatty acid , degradation, of unsaturated fatty acids with double bonds at odd-numbered carbon positions. It does so , by shifting the position of the double bonds in the acyl-CoA intermediates and converting 3-cis or , trans-enoyl-CoA to 2-trans-enoyl-CoA. UniProt Number: P42126, Gene ID: ECI1, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.