Anti-E4F1, clone PCRP-E4F1-2D1

Formulation: Purified Ab with BSA and Azide at 200ug/ml. Cellular Localization: Cytoplasm, Nucleoplasm, Nucleus. Positive Control: HeLa, Jurkat or MCF7 cells. Chromosome Location: 16p13.3. Protein Function: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription , Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes [The Uniprot Consortium]