Anti-E-Cadherin/ CD324 (Intercellular Junction Marker), clone SPM471

Formulation: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml. Cellular Localization: Adherens junction, Cell junction, Cell membrane, Endosome, Golgi apparatus, trans-Golgi network. Positive Control: LS174T, Raji or SK-BR3 cells. Human prostate or colon carcinomas. Chromosome Location: 16q22.1. Protein Function: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells. cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 , E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production , (Microbial infection) Serves as a receptor for Listeria monocytogenes. internalin A (InlA) binds to this protein and promotes uptake of the bacteria [The Uniprot Consortium]