Anti-DYRK1A

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-802A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A303-802A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Dual-specificity kinase which possesses both serine/threonine and tyrosine... more

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Product information "Anti-DYRK1A"

Protein function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis. [The UniProt Consortium]

Keywords:	Anti-DYRK, Anti-MNBH, Anti-hMNB, Anti-HP86, Anti-DYRK1A, Anti-Protein kinase minibrain homolog, Anti-Dual specificity YAK1-related kinase, Anti-Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-802A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat, X. laevis, X. tropicalis)
Immunogen:	synthetic peptide. The epitope recognized by A303-802A-T maps to a region between residue 713 abd 763 of human Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A using the numbering given in entry NP_001387.2 (GeneID 1859).
Format:	Antigen Affinity Purified