Anti-DUSP3 (Dual specificity protein phosphatase VHR, Vaccinia H1-related phosphatase)

DUSP3(Dual-specificity phosphatase 3), also called VHR, is a member of the dual specificity protein , phosphatase subfamily. DUSPs constitute a large heterogeneous subgroup of the type I cysteine-based , protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate , both tyrosine and serine/threonine residues. DUSP3 contains the consensus DUSP C-terminal catalytic , domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase , phosphatase) class of DUSPs. The DUSP3 gene is mapped on 17q21.31. Confocal microscopy , demonstrated that phosphorylated VHR accumulated at the immune synapse between the T cell and , the antigen-presenting cell in the presence of antigen. Tyrosine phosphorylation of VHR affects , protein-protein interaction, subcellular location, or substrate targeting, given that tyr138 is located on , the opposite side of the VHR catalytic center. UniProt Number: P51452, Gene ID: DUSP3, Applications: Suitable for use in Western Blot. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.