Anti-DSG1 / Desmoglein 1, clone MSVA-544M

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. DSG1 Antibody for IHC detects Desmoglein 1 (DSG1), a calcium-dependent desmosomal cadherin encoded by the DSG1 gene on chromosome 18q12.1. Desmoglein 1 is a single-pass transmembrane glycoprotein localized to desmosomes at the plasma membrane of stratified epithelial cells, where it mediates strong intercellular adhesion and preserves epidermal structural integrity. A DSG1 Antibody for IHC is commonly used to evaluate epithelial differentiation, barrier formation, and desmosomal integrity in tissue sections. This mouse monoclonal antibody clone MSVA-544M supports immunohistochemical detection of membranous DSG1 expression in formalin-fixed tissues.DSG1 antibody, also referred to as Desmoglein 1 antibody in the literature, recognizes a core structural component of desmosomal junctions within the cadherin superfamily. Its extracellular cadherin repeats mediate calcium-dependent homophilic adhesion between adjacent keratinocytes, while its cytoplasmic domain associates with desmosomal plaque proteins including Plakoglobin and Desmoplakin. Through these interactions, Desmoglein 1 anchors keratin intermediate filaments to the plasma membrane, reinforcing mechanical resilience in tissues exposed to friction and physical stress, particularly the epidermis and mucosal epithelium.Expression of DSG1 is predominantly observed in the suprabasal layers of stratified squamous epithelia, including skin, oral mucosa, and esophagus, where it is enriched in differentiated keratinocytes and contributes to epidermal stratification and barrier function. A DSG1 Antibody for IHC typically demonstrates strong membranous staining in suprabasal epithelial layers and is frequently used in studies of squamous differentiation and epithelial organization. Autoantibodies directed against Desmoglein 1 are implicated in pemphigus foliaceus, where disruption of desmosomal adhesion results in superficial epidermal blistering. Altered DSG1 expression has also been associated with inherited skin disorders and inflammatory conditions affecting epithelial cohesion.Structurally, Desmoglein 1 contains multiple extracellular cadherin domains, a transmembrane region, and an intracellular tail that connects to the desmosomal plaque complex. Beyond its structural role, Desmoglein 1 participates in signaling pathways that regulate keratinocyte differentiation and epidermal homeostasis. Dysregulated DSG1 expression may alter epithelial architecture and contribute to inflammatory or neoplastic processes in stratified epithelia. Through its essential role in maintaining desmosomal integrity, Desmoglein 1 remains central to research in epithelial biology, dermatologic disease mechanisms, and tumor-associated epithelial differentiation.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.