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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
D9300-50H.100 | 100 µg | - | - |
3 - 19 business days* |
662.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through... more
Product information "Anti-DR5 (Death Receptor 5, CD262, HGNC:11905, KILLER, TNF-related Apoptosis-inducing Ligand Recepto"
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB. Applications: Suitable for use in Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 5ug/ml, Immunohistochemistry: Paraffin, Optimal dilutions to be determined by the researcher. Positive Control: HL60 or Jurkat, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-TRAIL receptor 2, Anti-Death receptor 5, Anti-TNF-related apoptosis-inducing ligand receptor 2, Anti-Tumor necrosis factor receptor superfamily member 10B |
Supplier: | United States Biological |
Supplier-Nr: | D9300-50H |
Properties
Application: | FC, ICC, IF, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to aa388 to 407 (isoform 2) of human DR5 precursor. The same sequence is found in isoform 1 at aa417-436. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04722 | Matching products |
UniProt ID : | O14763 | Matching products |
Gene ID | GeneID 8795 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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