Anti-DPYD (Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase)

DPYD(Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded , by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial , and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of , the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid , strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and , 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of , DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no , significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood , mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA , microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was , identified as a positive regulator of DPYD. UniProt Number: Q12882, Gene ID: DPYD, Applications: Suitable for use in Western Blot. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.