Anti-DOG1 / TMEM16A / ANO1, clone DG1/1486

Anti-DOG1 / TMEM16A / ANO1, clone DG1/1486
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3473SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Expression of DOG-1 protein is elevated in the... more
Product information "Anti-DOG1 / TMEM16A / ANO1, clone DG1/1486"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%. Protein function: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. [The UniProt Consortium]
Keywords: Anti-ANO1, Anti-DOG1, Anti-Anoctamin-1, Anti-Transmembrane protein 16A, Anti-Oral cancer overexpressed protein 2, Anti-Tumor-amplified and overexpressed sequence 2, Anti-Discovered on gastrointestinal stromal tumors protein 1, DOG1 Antibody / TMEM16A / AN
Supplier: NSJ Bioreagents
Supplier-Nr: V3473SAF

Properties

Application: FC, IHC (paraffin), IF
Antibody Type: Monoclonal
Clone: DG1/1486
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A recombinant human protein corresponding to amino acids 2-101 of human DOG1 was used as the immunogen for this DOG1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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