Anti-DOG-1 Cocktail, clone DG1/447 + DOG-1.1

Anti-DOG-1 Cocktail, clone DG1/447 + DOG-1.1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3159IHC-7ML 7 ml - -

3 - 10 business days

Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-DOG-1 Cocktail, clone DG1/447 + DOG-1.1"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%. Protein function: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. [The UniProt Consortium]
Keywords: Anti-DOG1, Anti-ANO1, Anti-Anoctamin-1, Anti-Transmembrane protein 16A, Anti-Oral cancer overexpressed protein 2, Anti-Tumor-amplified and overexpressed sequence 2, Anti-Discovered on gastrointestinal stromal tumors protein 1, DOG-1 Antibody Cocktail
Supplier: NSJ Bioreagents
Supplier-Nr: V3159IHC-7ML


Application: IHC
Antibody Type: Mixed
Clone: DG1/447 + DOG-1.1
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human DOG1 protein (DG1/447) and amino acids 904-986 (DOG-1.1) were used as the immunogens for this DOG-1 antibody cocktail.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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