Anti-DNASE1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA010703.25	25 µl		-		7 - 10 business days*		330.00€
ATA-HPA010703.100	100 µl		-		7 - 10 business days*		463.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and... more

Close menu

Product information "Anti-DNASE1"

Protein function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 81% and to rat: 78%

Keywords:	Anti-DNL1, Anti-DNase I, Anti-Dornase alfa, Anti-Deoxyribonuclease-1, Anti-Deoxyribonuclease I
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA010703

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: YVRPSQWSSI RLWTSPTFQW LIPDSADTTA TPTHCAYDRI VVAGMLLRGA VVPDSALPFN FQAAYGLSDQ LAQAISDHY (ATA-APrEST71906)