Anti-DNA-PKcs

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-967A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-967A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-967A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage.... more
Product information "Anti-DNA-PKcs"
Protein function: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2, negatively regulates CRY1 phosphorylation. [The UniProt Consortium]
Keywords: Anti-p460, Anti-HYRC, Anti-DNPK1, Anti-PRKDC, Anti-DNA-PKcs, EC=2.7.11.1, Anti-DNA-PK catalytic subunit, Anti-DNA-dependent protein kinase catalytic subunit
Supplier: Bethyl Laboratories
Supplier-Nr: A303-967A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Reactivity: Human (Expected: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A303-967A-T maps to a region between residue 4078 to 4128 of human Protein Kinase, DNA-Activated, Catalytic Polypeptide using the numbering given in entry NP_008835.5 (GeneID 5591).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-DNA-PKcs"
Write a review
or to review a product.
Viewed