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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ARG58524.50 | 50 µg | - | - |
10 - 15 business days* |
538.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Transcription factor that plays a key role in male sex determination and... more
Product information "Anti-DMRT1"
Protein function: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. [The UniProt Consortium]
| Keywords: | Anti-DMT1, Anti-DMRT1, Anti-DM domain expressed in testis protein 1, Anti-Doublesex- and mab-3-related transcription factor 1 |
| Supplier: | Arigo Biolaboratories |
| Supplier-Nr: | ARG58524 |
Properties
| Application: | IHC (paraffin), WB |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat (Expected: hamster) |
| Immunogen: | Synthetic peptide corresponding to a sequence at the N-terminus of Human DMRT1 (98-128aa RDCQCKKCNLIAERQRVMAAQVALRRQQAQE), different from the related Mouse sequence by one amino acid |
| MW: | 39 kD |
| Format: | Antigen Affinity Purified |
Database Information
| KEGG ID : | K19488 | Matching products |
| UniProt ID : | Q9Y5R6 | Matching products |
| Gene ID : | GeneID 1761 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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