Anti-DLG3

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009], Protein function: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: extracellular space,cytoplasm,plasma membrane,bicellular tight junction,ionotropic glutamate receptor complex,postsynaptic density,basolateral plasma membrane,growth cone,AMPA glutamate receptor complex,neuronal cell body,d