Anti-DIS3

Anti-DIS3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-764A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-764A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-764A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Putative catalytic component of the RNA exosome complex which has 3'->5'... more
Product information "Anti-DIS3"
Protein function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. [The UniProt Consortium]
Keywords: Anti-DIS3, Anti-KIAA1008, EC=3.1.26.-, EC=3.1.13.-, Anti-Protein DIS3 homolog, Anti-Exosome complex exonuclease RRP44, Anti-Ribosomal RNA-processing protein 44
Supplier: Bethyl Laboratories
Supplier-Nr: A303-764A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rat, Bovine, Dog, Horse, Rabbit, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Small-eared Galago, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-764A-T maps to a region between residue 1 and 50 of human DIS3 mitotic control homolog using the numbering given in entry NP_055768.3 (GeneID 22894).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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