Anti-DICER1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-13197.20 20 µl -

7 - 16 business days*

71.00€
E-AB-13197.60 60 µl -

7 - 16 business days*

143.00€
E-AB-13197.120 120 µl -

7 - 16 business days*

238.00€
E-AB-13197.200 200 µl -

7 - 16 business days*

396.00€
 
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino... more
Product information "Anti-DICER1"
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. Protein function: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. [The UniProt Consortium]
Keywords: Anti-DICER, Anti-DICER1, EC=3.1.26.3, Anti-Helicase MOI, Anti-Endoribonuclease Dicer, Anti-Helicase with RNase motif, DICER1 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-13197

Properties

Application: IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Synthetic peptide of human DICER1
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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