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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A300-077A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A300-077A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for... more
Product information "Anti-Diaphanous 1"
Protein function: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). [The UniProt Consortium]
Keywords: | Anti-DRF1, Anti-DIAP1, Anti-DIAPH1, Anti-Diaphanous-related formin-1, Anti-Protein diaphanous homolog 1 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A300-077A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: pig, orangutan, white-tufted-ear marmoset) |
Immunogen: | synthetic peptide. The epitope recognized by A300-077A-T maps to a region between residues 1 and 50 of human Diaphanous Homolog 1 using the numbering given in entry NP_005210.1 (GeneID 1729). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K05740 | Matching products |
UniProt ID : | O60610 | Matching products |
Gene ID | GeneID 1729 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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