Anti-DHX58 / DExH-box helicase 58

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. DHX58 antibody detects DExH-box helicase 58, also known as LGP2, a cytoplasmic RNA helicase that functions as a regulator of antiviral innate immune responses. DHX58 belongs to the RIG-I-like receptor (RLR) family, which includes RIG-I and MDA5, and is involved in sensing viral RNA to trigger interferon production. The DHX58 antibody is widely used in immunology, virology, and innate signaling research to study viral RNA recognition and interferon pathway regulation.DHX58 is encoded by the DHX58 gene located on human chromosome 17q21.1. The protein is approximately 678 amino acids long and contains a helicase core domain, ATP-binding motifs, and a C-terminal regulatory domain. Unlike RIG-I and MDA5, DHX58 lacks the N-terminal CARD domains required for direct signaling, functioning instead as a modulator of their activity. It localizes to the cytoplasm and associates with stress granules and viral replication complexes during infection.The DHX58 antibody detects a 75 kilodalton band by western blot and exhibits punctate cytoplasmic staining by immunofluorescence microscopy. DHX58 acts as a positive or negative regulator of antiviral signaling depending on context. It binds double-stranded RNA and modulates the activity of MDA5 and RIG-I, fine-tuning the magnitude and duration of type I interferon responses. During viral infection, DHX58 helps discriminate self from non-self RNA, preventing inappropriate immune activation.Mutations or altered expression of DHX58 affect susceptibility to viral pathogens such as influenza, hepatitis C, and coronaviruses. It also influences autoimmunity, where excessive activation of the RLR pathway leads to chronic inflammation and tissue damage. Beyond immunity, DHX58 participates in RNA metabolism and stress granule dynamics, linking it to translational control during cellular stress.As a key regulator of antiviral sensing, DHX58 provides a molecular handle for understanding innate immune balance and pathogen recognition. NSJ Bioreagents provides a validated DHX58 antibody optimized for its applications, supporting research into host defense, interferon regulation, and viral pathogenesis.