Anti-DHX33

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-799A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-799A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis... more

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Product information "Anti-DHX33"

Protein function: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF- kappa-B signaling pathways. [The UniProt Consortium]

Keywords:	Anti-DDX33, EC=3.6.4.13, Anti-DEAH box protein 33, Anti-ATP-dependent RNA helicase DHX33
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-799A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: horse, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, african elephant, small-eared galago, thirteen-lined ground squirrel)
Immunogen:	synthetic peptide. The epitope recognized by A300-799A-T maps to a region between residue 1 and 50 of human DEAH (Asp-Glu-Ala-His) Box Polypeptide 33 using the numbering given in entry NP_064547.2 (GeneID 56919).
Format:	Antigen Affinity Purified