Anti-Desmoglein 3 / DSG3, clone MSVA-543M

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. DSG3 Antibody for IHC detects Desmoglein 3 (DSG3), a calcium-dependent desmosomal cadherin encoded by the DSG3 gene on chromosome 18q12.1. Desmoglein 3 is a single-pass transmembrane glycoprotein localized to desmosomes at the plasma membrane of stratified epithelial cells, where it mediates strong intercellular adhesion and maintains tissue cohesion. A DSG3 Antibody for IHC is commonly used to evaluate epithelial differentiation, mucocutaneous integrity, and squamous cell carcinoma biology in formalin-fixed tissue sections. This mouse monoclonal antibody clone MSVA-543M supports detection of membranous DSG3 expression in epithelial tissues. This antibody is part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.DSG3 antibody, also referred to as Desmoglein 3 antibody in the literature, recognizes a core structural component of desmosomal junctions within the cadherin superfamily. Its extracellular cadherin repeats enable calcium-dependent homophilic adhesion between adjacent epithelial cells, while its intracellular domain associates with desmosomal plaque proteins including Plakoglobin and Desmoplakin. Through these interactions, Desmoglein 3 anchors keratin intermediate filaments to the plasma membrane, reinforcing epithelial cohesion in tissues subjected to mechanical stress, particularly the epidermis and mucosal surfaces.Expression of DSG3 is most prominent in the basal and immediate suprabasal layers of stratified squamous epithelia, including oral mucosa, esophagus, cervix, and epidermis. In contrast to Desmoglein 1, which is enriched in superficial epidermal layers, Desmoglein 3 is concentrated in deeper epithelial layers and plays a central role in maintaining mucocutaneous stability. A DSG3 Antibody for IHC typically demonstrates strong membranous staining in these basal epithelial compartments and is frequently used in studies of squamous differentiation and epithelial organization. Autoantibodies directed against Desmoglein 3 are strongly associated with pemphigus vulgaris, where disruption of desmosomal adhesion leads to intraepidermal blister formation. Altered DSG3 expression has also been reported in squamous cell carcinoma and other epithelial malignancies, where desmosomal remodeling may influence tumor differentiation and invasion patterns.Structurally, Desmoglein 3 contains multiple extracellular cadherin domains, a transmembrane region, and an intracellular tail that integrates into the desmosomal plaque complex. Beyond its adhesive role, DSG3 participates in signaling pathways regulating keratinocyte proliferation, differentiation, and epithelial homeostasis. Dysregulated expression may alter epithelial architecture and contribute to inflammatory or neoplastic processes. Through its essential function in desmosomal integrity, Desmoglein 3 remains a key marker in epithelial biology, dermatologic disease research, and tumor-associated epithelial differentiation.Explore our Desmoglein 3 Antibody - Human Protein Microarray Validated Clone DSG3/2838 page for a broader view of DSG3 expression in stratified epithelia with supporting microarray specificity validation data.