Anti-Desmoglein 3

Anti-Desmoglein 3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R30643 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Desmoglein 3 is also known as PVA... more
Product information "Anti-Desmoglein 3"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Desmoglein 3 is also known as PVA (Pemphigus Vulgaris Antigen). Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune diseases of the skin which have as target antigens two different members of the desmoglein subfamily of the desmosomal cadherins: pemphigus vulgaris antigen (PVA, or Desmoglein 3) in the case of PV and Desmoglein 1 in the case of PF. The DSG3 gene, like the genes for DSG1 and DSG2, is located on chromosome 18. The human DSG3 gene consists of 15 exons and spans more than 23 kb. DSG3 and DSG1 are the autoantigens of pemphigus vulgaris and pemphigus foliaceus, respectively. DSG3 and DSG1 are the target antigens in PNP, and IgG autoantibodies against DSG3 in PNP sera play a pathogenic role in the loss of keratinocyte adhesion and blistering. Protein function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. [The UniProt Consortium]
Keywords: Anti-PVA, Anti-CDHF6, Anti-Desmoglein-3, Anti-Cadherin family member 6, Anti-130 kDa pemphigus vulgaris antigen, Desmoglein 3 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R30643

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Amino acids 981-999 (QLRGSHTMLCTEDPCSRLI-human )
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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